Bridge GLP compliant drug development in the US & China

DART

Overview

Bridge has performed Developmental and Reproductive Toxicology (DART) studies at its US facility for more than a decade. DART is an important specialization within the comprehensive Bridge preclinical toxicology offering, which is why we maintain a dedicated DART facility in the US to support ongoing client research. Our technical staff has the deep DART experience and expertise required to carry out the full range of GLP-compliant DART studies — studies that meet the highest scientific and regulatory standards (ICH, FDA, EPA, OECD, EU and MOHW).

Wide Range of DART Services

Our DART expertise and capabilities can be utilized by clients across a broad array of study types, including:

At Bridge, we are experienced and skilled in undertaking DART studies that utilize both routine and specialized routes of administration:

  • Continuous infusion

  • Dermal

  • Dietary

  • Intramuscular

  • Intravenous

  • Oral (gavage, water, capsule)

  • Rectal

  • Vaginal

Services to Meet Specialized Requirements

We offer a number of specialized services to satisfy unique client research requirements. For example, we can perform spermatogenesis evaluations of cellular endpoints (morphology, motility, spermatid head count) via the Hamilton-Thorne IVOS Cell Analysis System. We can also carry out vaginal cytology evaluations for both the pharmaceutical industry and the National Toxicology Program (NTP).

 

In addition, Bridge maintains a full-service teratology laboratory on-site that includes both teratology and necropsy suites furnished with the latest technology and equipment to meet specific client and species needs.

Bridge’s specialized DART services include:

  • Pharmacokinetics/toxicokinetics

    • Amniotic fluid collection

    • Fetal blood

    • Milk collection

    • Parental/maternal plasma samples

  • Postnatal development capabilities

    • Neurotoxicity behavior tests

      • Functional Observation Battery (FOB modified Irwin Method)

      • Motor activity

      • Passive avoidance

      • Startle response evaluation

    • Markers of physical and sexual development

      • Anogenital Distance (AGD)

      • Eye opening

      • Incisor eruption

      • Pinna unfolding

      • Preputial separation

      • Testicular descent

      • Vaginal opening
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